Dr. Ya-Ting Kao
高雅婷 博士

 

 

Position

Assistant Professor, Department of Biological Science and Technology, National Chiao Tung University, Taiwan. (Aug. 2012 - )

Postdoctoral Associate, Department of Chemistry, Columbia University. (Sep. 2010 - Jul. 2012, Advisor: Prof. Wei Min)

Teaching Assistant, Department of Chemistry, The Ohio State University, USA. (2004 - 2007)

 

Research Interests

Femtobiology, Conformational dynamics of biological macromolecules. Femtosecond spectroscopy, Single molecule spectroscopy, and Single molecule microscopy.

 

Education

Ph.D. Department of Chemistry, The Ohio State University, Jun. 2010. (Advisor: Prof. Dongping Zhong)

M.S. Department of Chemistry, National Tsing Hua University, Taiwan, 2000. (Advisor: Prof. I-Chia Chen)

B.S. Department of Chemistry, National Tsing Hua University, Taiwan, 1998

 

Honors

Presidential Fellowship The Ohio State Graduate School, 2008-2009

Student Travel Award 50th Biophysical Society Annual Meeting, 2006

Research Excellence Award 7th International Femtochemistry Conference, 2005

Academic Achievement Award National Tsing Hau university, 1997

Tasco Chemical Corporation Scholarship Tasco Chemical Corporation, 1997

Publication (reverse chronological order)

21. Z. Liu, C. Tan, X. Guo, Y.-T. Kao, J. Li, L. Wang, A. Sancar, and D. Zhong. Dynamics and mechanism of cyclobutane pyrimidine dimer repair by DNA photolyase. Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 14831 -14836.

20. E. Gatzogiannis, X. Zhu, Y.-T. Kao and W. Min. Observation of frequency-domain fluorescence anomalous phase advance due to dark state hysteresis, J. Phys. Chem. Lett. 2011, 2, 461.

19. C.-W. Chang, L. Guo, Y.-T. Kao, J. Li, C. Tan, T. Li, C. Saxena, Z. Liu, L. Wang, A. Sancar and D. Zhong. Ultrafast solvation dynamics at binding and active sites of photolyases. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 2914 -2919.

18. J. Stevens, J. Link, Y.-T. Kao, C. Zang, L. Wang and D. Zhong. Ultrafast dynamics of resonance energy transfer in myoglobin: Probing local conformation fluctuations. J. Phys. Chem. B 2010, 114, 1498-1505.

17. N. Ö ztürk, C. Selby, S.-H. Song, R. Ye, C. Tan, Y.-T. Kao, D. Zhong and A. Sancar. Comparative photochemistry of animal type 1 and type 4 cryptochromes. Biochemistry 2009, 48, 8585-8593.

16. L. Zhang, Y. Yang, Y.-T. Kao, L. Wang and D. Zhong. Protein hydration dynamics and molecular mechanism of coupled water-protein fluctuations J. Am. Chem. Soc. 2009, 131, 10677-10691.

15. Y.-T. Kao, C. Saxena, T.-F. He, L. Guo, L. Wang, A. Sancar and D. Zhong. Ultrafast dynamics of flavins in five redox states. J. Am. Chem. Soc. 2008, 130, 13132-13139.

14. N. Ö ztürk, Y.-T. Kao, C. Selby, I. Kavakli, C. Partch, D. Zhong and A. Sancar. Purification and characterization of a type III photolyase from Caulobacter crescentus. Biochemistry 2008, 47, 10255-10261.

13. Y.-T. Kao, C. Tan, S.-H. Song, N. Ö ztürk, J. Li, L. Wang, A. Sancar and D. Zhong. Ultrafast dynamics and anionic active states of flavin cofactor in cryptochrome and photolyase. J. Am. Chem. Soc. 2008, 130, 7695-7701.

12. W. Qiu, T. Li, L. Zhang, Y. Yang, Y.-T. Kao, L. Wang and D. Zhong. Ultrafast quenching of tryptophan fluorescence in proteins: interresidue and intrahelical electron transfer. Chem. Phys. 2008, 350, 154-164.

11. L. Zhang, L. Wang, Y.-T. Kao, W. Qiu, Y. Yang, O. Okobiah and D. Zhong. Mapping hydration dynamics around a protein surface. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 18461-18466.

10. S.-H. Song, N. Ö ztürk, T. Denaro, N. Arat, Y.-T. Kao, H. Zhu, D. Zhong, S. M. Reppert and A. Sancar. Formation and function of flavin anion radical in cryptochrome 1 blue-light photoreceptor of monarch butterfly. J. Biol. Chem. 2007, 282, 17608-17612.

9. Y.-T. Kao, C. Saxena, L. Wang, A. Sancar and D. Zhong. Femtochemistry in enzyme catalysis: DNA photolyase. Cell Biochem. Biophys. 2007, 48, 32-44. (invited review)

8. T. Li, A. Hassanali, Y.-T. Kao, D. Zhong and S. Singer. Hydration dynamics and time scales of couple water-protein fluctuations. J. Am. Chem. Soc. 2007, 129, 3376-3382.

7. W. Qiu, Y.-T. Kao, L. Zhang, Y. Yang, L. Wang, W. Stites, D. Zhong and A. Zewail. Protein surface hydration mapped by site-specific mutations. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 13979-13984.

6. L. Zhang, Y.-T. Kao, W. Qiu, L. Wang and D. Zhong. Femtosecond studies of tryptophan fluorescence dynamics in proteins: Local solvation and electronic quenching. J. Phys. Chem. B 2006, 110, 18097-18103.

5. C. Saxena, Y.-T. Kao, L. Wang, A. Sancar and D. Zhong. Direct observation of DNA repair by photolyase. In Femtochemistry VII: Fundamental Ultrafast Processes in Chemistry, Physics, and Biology, A. W. Castleman, Jr., M. L. Kimble, eds., Elsevier: Amsterdam 2006, p407.

4. Y.-T. Kao, C. Saxena, L. Wang, A. Sancar and D. Zhong. Direct observation of thymine dimer repair in DNA by photolyase. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 16128-16132.

3. W. Qiu, L. Zhang, Y.-T. Kao, W. Lu, T. Li, J. Kim, G. Sollenberger, L. Wang and D. Zhong. Ultrafast hydration dynamics in melittin folding and aggregation: Helix formation and tetramer self-assembly. J. Phys. Chem. B 2005, 109, 16901-16910.

2. C.-W. Chang, Y.-T. Kao and E. W.-G. Diau. Fluorescence lifetime and nonradiative relaxation dynamics of DCM in nonpolar solvent. Chem. Phys. Lett. 2003, 374, 110-118.

1. Y.-T. Kao, W.-C. Chen, C.-H. Yu and I-C. Chen. Production of HCO from propenal photolyzed at 193 nm: relaxation of excited states and distribution of internal states of fragment HCO. J. Chem. Phys. 2001, 114, 8964-8970.

Contributed Presentations (reverse chronological order)

9. Y.-T. Kao, Invited Talk in Department of Chemistry at National Tsing Hua University (August 25, 2010, Hsinchu, Taiwan ) Ultrafast dynamics of flavin cofactor in DNA repair by photolyase and in signaling formation of cryptochrome.

8. Y.-T. Kao, C. Saxena, L. Wang and D. Zhong, 23rd Edward F. Hayes Graduate Research Forum (April 25, 2009, Columbus, Ohio) Functional dynamics and molecular mechanism of photolyase.

7. Y.-T. Kao, C. Saxena, T.-F. He, L. Guo, L. Wang and D. Zhong, Evans Lectures (October 18, 2008, Columbus, Ohio) Ultrafast dynamics of flavins in five redox states.

6. Y.-T. Kao, C. Tan, J. Li, L. Wang and D. Zhong, 63rd Ohio State University International Symposium on Molecular Spectroscopy (June 16-20, 2008, Columbus, Ohio) Ultrafast dynamics and anionic active states of cofactor flavin in cryptochrome and photolyase.

5. Y.-T. Kao, C. Saxena, L. Wang and D. Zhong, 22nd Edward F. Hayes Graduate Research Forum (April 12, 2008, Columbus, Ohio) Direct observation of cyclobutane pyrimidine dimer repair in DNA by photolyase.

4. Y.-T. Kao, C. Saxena, L. Wang and D. Zhong, 50th Biophysical Society Annual Meeting (February 18-22, 2006, Salt

Lake City, Utah) Direct observation of thymine dimer repair in DNA by photolyase.

3. Y.-T. Kao, C. Saxena, L. Wang and D. Zhong, 7th International Femtochemistry Conference (July 17-21, 2005, Washington, D.C.) Direct observation of DNA repair in photolyase

2. Y.-T. Kao, C. Saxena, L. Wang and D. Zhong, 2005 Cross Border Workshop on Laser Science (June 23-25, 2005, Columbus, Ohio) Direct observation of thymine dimer repair in DNA by photolyase.

1. Y.-T. Kao, C. Saxena and D. Zhong, 60th Ohio State University International Symposium on Molecular Spectroscopy (June 20-24, 2005, Columbus, Ohio) Direct observation of thymine repair in DNA by photolyase.